- 2009 B.S. Pharmaceutical Science, University of Missouri-Kansas City
Hypoxia inducible factor-1α (HIF-1α) is a transcription factor which plays an important role in promoting cellular adaptation to ischemic conditions. Recently, HIF-1 is focused on as a potential target for stroke therapy as it appears to have many beneficial roles in the ischemic brain. My current research is focused on understanding the mechanisms that lead to HIF-1 degradation and stabilization. This involves targeting the mechanisms of reactive oxygen species formation and the activities of proteasomal degradation pathways. Taking advantage of HIF-1 stabilization in the ischemic brain may prove to be beneficial in reducing brain damage following a stroke.