It has been shown that chronic stress alters the functioning of the hypothalamic–pituitary–adrenal (HPA) axis, but the downstream influences on metabolism and the peripheral nervous system have been poorly studied. The adenosine A1 receptor has been shown to have anti-nociceptive benefits and can be activated by a ketogenic diet or exercise. Therefore, I am developing a chronic stress model in mouse to understand how exercise- or ketogenic diet-induced adenosine A1 receptor activation may alter HPA axis output, metabolism, and behavioral evidence of pain and affective disorders.
Joined the NS program year of 2015.
Mentor: Douglas E. Wright, Ph.D., Julie A. Carlsten Christianson, Ph.D.
Mentor’s Academic Department: Anatomy and Cell Biology, KUMC
Leung YM, Tsou YH, Kuo CS, Lin SY, Wu PY, Hour MJ, Kuo YH. Arylnaphthalene Lignans from Taiwania Cryptomerioides as Novel Blockers of Voltage-Gated K+ Channels, Phytomedicine. (2010 Dec 15; 18 (1): 46-51. Epub 2010 Jun 1)
Selected Awards & Honors
Service Award, 06/2012; Leadership Scholarship, 09/2010 in China Medical University, Taiwan.