Over 100 million American currently have pre or frank diabetes, and 70% of all diabetics will develop a peripheral neuropathy. My work is examining how physical activity may provide a benefit in prediabetes to rescue the development of a painful neuropathy often seen in patients. I am examining how a high fat diet and inflammation may lead to an increase in molecular signaling in peripheral nerves, leading to a mechanical painful sensitivity, and how exercise’s numerous benefits in turn reduce or inhibit these molecular signals to provide relief.
Year Joined: Fall 2013
Mentor: Doug Wright, Ph.D.
Academic Department: Anatomy and Cell Biology, KUMC
- Cooper, M.A., P.M. Kluding, D.E. Wright (2016). Emerging Relationships Between Exercise, Sensory Nerves, and Neuropathic Pain. Frontiers in Neuroscience
- Cooper, M.A., J. Ryals, K. Wright, K. Walter, P. Yen-Wu, D. Wright (2016). Exercise Drive Alterations of High-Fat Diet Induced Mechanical Allodynia. Oral Presentation: 2016 Student Research Forum, Kansas University Medical Center, Kansas City, KS, USA
- Cooper, M.A., J.M. Ryals, D.E. Wright (2015). Exercise-induced genetic alterations in high-fat pre-diabetic mouse dorsal root ganglia. American Diabetes Association, Boston, MA, USA June 2015
- Cooper, M.A., J.M. Ryals, D.E. Wright (2015). Genetic alterations in high-fat pre-diabetic exercised and sedentary mouse sensory nerve bodies. Oral Presentation: 2015 Student Research Forum, Kansas University Medical Center, Kansas City, KS, USA
- Cooper, M.A., N.W. Grossman, J.M. Ryals, D.E. Wright (2014). Painful neuropathy induced by a high-fat diet is reduced by restricted exercise in prediabetic C57BL/6 mice. Oral Presentation: 2014 Student Research Forum, Kansas University Medical Center, Kansas City, KS, USA
Selected Awards & Honors
Lila & Madison Self Fellowship, 1st Place Oral Presentation Session 2 KUMC Student Research Forum