Joe Farthing, M.S.

Mentor: Eduardo Rosa-Molinar, Ph.D. - Mentor’s Academic Department: Pharmacology and Toxicology, KU-Lawrence
Primary office:


Three-dimensional (3-D) tissue modeling is an emerging field of investigation to elucidate tumor metastasis, cellular and tissue architectures and forces, rational drug design, and in vitro drug testing. In an academic-industry collaborative project in the Rosa-Molinar laboratory, we are using correlative in-resin volume electron microscopy to study nanoscale cellular components in 3-D tissues models, such as in vitro organoid and organ-on-chip, that simulate in vivo interactions between brain tumor and non-brain tumor cells. The aim of the work is to identify and describe the spatial-temporal expression of inflammatory mediators and infiltration of inflammatory cells within a brain tumor microenvironment. We are specifically interested in studying "tumor-to-tumor" metastasis and concomitantly resolving several critical shortcomings in the above-mentioned emerging technologies, specifically, reproducing non-tumor and tumor in vivo brain microenvironment parameters in vitro, reproducing accurate brain cellular architecture and forces, and providing real-time 3-D visualization capability.

Memberships

Mentor: Eduardo Rosa-Molinar, Ph.D.

Mentor’s Academic Department: Pharmacology and Toxicology, KU-Lawrence

Academic year joined the NS program: 2017


Contact Information

The University of Kansas
Neuroscience Graduate Program
c/o Dr. Rick Dobrowsky
School of Pharmacy, Ste 2001-D
2010 Becker Drive
Lawrence, KS 66047
Telephone: (785) 864-3531 or (785) 864-3893
E-mail: dobrowsky@ku.edu or psteffan@ku.edu

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