Isabella Fuentes, B.S.

Primary office:


My project focuses on a mouse model of chronic prostatitis/chronic pelvic pain syndrome with comorbid mood disorders using neonatal maternal separation to induce early life stress. This model is utilized to investigate the underlying mechanisms of debilitating comorbid mood and functional pain disorders, as well as voluntary running wheel exercise as a potential intervention to attenuate symptoms and/or pathophysiology. My particular interest is how early life stress effects the hypothalamic-pituitary-adrenal axis and influences chronic pelvic pain and comorbid mood disturbances in this model.

Memberships

Academic year joined to the NS program: 2012-2013

Mentor: Julie A. Christianson, Ph.D.

Mentor’s Academic Department: Anatomy and Cell Biology, KUMC

Selected Publications

Papers:

Fuentes IM, Walker NK, Pierce AN, Holt BR, Di Silvestro ER, Christianson JA. (2016) Neonatal maternal separation increases susceptibility to experimental colitis and acute stress exposure in male mice. IBRO Reports. In press.

Raider KD, Ma D, Harris JL, Fuentes IM, Rogers RS, Wheatley JL, Geiger PC, Yeh H, Choi I, Brooks WM, Stanford JA. (2016) A high fat diet alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study. Neurochemistry International; 97, 172-80.

Pierce AN, Zhang Z, Fuentes IM, Wang R, Ryals JM, Christianson JA. (2015) Early-life vaginal irritation results in long-term vaginal and somatic hypersensitivity and increased hypothalamic-pituitary-adrenal axis output in female mice. Pain; 156(10), 2021-31. Chosen as an “Editor’s Choice” article.

Fuentes IM, Pierce AN, O’Neil PT, Christianson JA. (2015) Assessment of perigenital sensitivity and prostatic mast cell activation in mouse model of neonatal maternal separation. Journal of Video Experiments; 102, e53181.

 

Published Abstracts:

Fuentes IM, Eller OC, Pierce AN, Christianson JA. (2016) Sex differences in an early lie stress mouse model of comorbid mood disorder and urogenital pain. American Pain Society Annual Meeting.

Fuentes IM, Pierce AN, Wang R, Christianson JA. (2015) Voluntary exercise can prevent or reverse comorbid urogenital and mood disorders resulting from early life stress in male mice. Society for Neuroscience Annual Meeting.

Fuentes IM, Pierce AN, Wang R, Christianson JA. (2015) The impact of early or late voluntary exercise interventions on early life stress-induced comorbid mood and urogenital pain disorders in male mice. American Pain Society Annual Meeting.

This poster was also presented at the Overcoming Barriers to Translation of Pain Research Symposium at the University of Pittsburgh, June 2015.

Pierce AN, Fuentes IM, Wang R, Ryals JM, Christianson JA. (2015) Hypothalamic-pituitary-adrenal axis activation drives cross-sensitization following neonatal vaginal irritation in mice. American Pain Society Annual Meeting.

Fuentes IM, Pierce AN, Wang R, Christianson JA. (2014) The impact of early life stress and voluntary exercise intervention on comorbid mood and urogenital pain disorders in male mice. Society for Neuroscience Annual Meeting.

Christianson JA, Pierce AN, Fuentes IM. (2014) Exercise-induced attenuation of comorbid mood and urogenital disorders in mice that underwent neonatal maternal separation. International Association for the Study of Pain 15th World Congress on Pain.

Fuentes IM, Pierce AN, Walker NK, Holt BR, Wang R, Ryals JM, Christianson JA. (2013) Impact of early life and adult stress on anxiety behavior and pelvic organ sensitivity in male mice. Society for Neuroscience Annual Meeting.

Fuentes IM, Frost NL, Nguyen DT, Mickey KE, Thai L, Bellem A, Le MP, Scholes CM, Chapman JM. (2012) Characterization of the chemical constituents of Korean herbal extracts by bioassay-guided fractionation. American Chemistry Society National Meeting & Exposition.

Fuentes IM, Frost N, Chapman JM. (2011) Characterization of the chemical constituents of Chinese and Korean Jakyak root and correlation to medicinal activity. 46th Midwest/39th Great Lakes Joint Regional Meeting of the American Chemistry Society.

Selected Awards & Honors

  • American Pain Society Young Investigator Travel Award, 2016
  • Paul B. Freeburg Award, 2016
  • Student Research Forum Oral Presentation, 3rd Place Overall, 2016
  • Student Research Forum Oral Presentation Session A, 1st Place, 2016
  • Student Research Forum Oral Presentation Session G, 2nd Place, 2015
  • Student Governing Council Travel Award, 2014
  • Neurological and Rehabilitation Sciences Training Program (T32 Training Grant), 2014-present

Contact Information

The University of Kansas
Neuroscience Graduate Program
c/o Dr. Rick Dobrowsky
School of Pharmacy, Ste 2001-D
2010 Becker Drive
Lawrence, KS 66047
Telephone: (785) 864-3531 or (785) 864-3893
E-mail: dobrowsky@ku.edu or psteffan@ku.edu

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