My project aims to determine if there is a link between changes in mitochondrial respiration and levels of tau cleavage. Tau is a microtubule associated protein which aggregates into tangles in the brains of patients with Alzheimer’s disease. Cleaved fragments of tau are common in tangles; however, it is unclear what cellular events favor tau cleavage. Mitochondrial function is a promising as a potential modulator of tau cleavage because it has been shown to affect other aspects of tau processing.
Year joined IGPBS: 2014
Mentor: Russel Swerdlow, M.D.
Mentor's Academic Department: Joint appointments in Departments of Neurology, Molecular and Integrative Physiology, Biochemistry and Molecular Biology
Weidling, I. and Swerdlow, RH. (2016) "The ABCD's of 5'-adenosine monophosphate-activated protein kinase and adrenoleukodystrophy." J Neurochem; 138(1), 10-13.
Wilkins H. M., Koppel S., Carl SM, Ramanujan S, Weidling I., Michaelis ML, Michaelis EK, Swerdlow RH. (2016) "Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure." J Neurochem; 137(1), 76-87.