Ian Weidling, B.S.

Primary office:


My project aims to determine if there is a link between changes in mitochondrial respiration and levels of tau cleavage. Tau is a microtubule associated protein which aggregates into tangles in the brains of patients with Alzheimer’s disease. Cleaved fragments of tau are common in tangles; however, it is unclear what cellular events favor tau cleavage. Mitochondrial function is a promising as a potential modulator of tau cleavage because it has been shown to affect other aspects of tau processing.

Memberships

Year joined IGPBS: 2014

Mentor: Russel Swerdlow, M.D.

Mentor's Academic Department: Joint appointments in Departments of Neurology, Molecular and Integrative Physiology, Biochemistry and Molecular Biology

Selected Publications

Weidling, I. and Swerdlow, RH. (2016) "The ABCD's of 5'-adenosine monophosphate-activated protein kinase and adrenoleukodystrophy." J Neurochem; 138(1), 10-13.

Wilkins H. M., Koppel S., Carl SM, Ramanujan S, Weidling I., Michaelis ML, Michaelis EK, Swerdlow RH. (2016) "Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure." J Neurochem; 137(1), 76-87.


Contact Information

The University of Kansas
Neuroscience Graduate Program
c/o Dr. Rick Dobrowsky
School of Pharmacy, Ste 2001-D
2010 Becker Drive
Lawrence, KS 66047
Telephone: (785) 864-3531 or (785) 864-3893
E-mail: dobrowsky@ku.edu or psteffan@ku.edu

One of 34 U.S. public institutions in the prestigious Association of American Universities
44 nationally ranked graduate programs.
—U.S. News & World Report
Top 50 nationwide for size of library collection.
—ALA
23rd nationwide for service to veterans —"Best for Vets," Military Times
KU Today