KU-Lawrence Campus (KU-L)
Three-dimensional (3-D) tissue modeling is an emerging field of investigation to elucidate tumor metastasis, cellular and tissue architectures and forces, rational drug design, and in vitro drug testing.
To determine the distance between connexin containing gap junctions using a combination of acceptor photo-bleaching FRET and electron microscopy in a new technique we refer to as correlative FRET (cFRET).
If you project is not yet set, just write about the focus of the lab and potential projects that you might work on.
My project focuses on axo-somatic mixed synapses (conjoined electrical [i.e. gap junctions] and chemical synapses) between spinal inhibitory interneurons (i.e., VIa) and spinal motor neurons.
KU-Medical Center Campus (KUMC)
Over 100 million American currently have pre or frank diabetes, and 70% of all diabetics will develop a peripheral neuropathy. My work is examining how physical activity may provide a benefit in prediabetes to rescue the development of a painful neuropathy often seen in patients.
Although migraine headache is one of the most common neurological disorders, the underlying mechanism triggering migraine is still poorly understood. Migraine sufferers often display comorbid pain disorders including interstitial cystitis, vulvodynia or chronic prostatitis, and fibromyalgia.
Diabetes mellitus affects roughly one-tenth of the US population leading to significant morbidity and mortality.
The ketogenic diet and its featured metabolite, ketone bodies, have a well-recognized therapeutic role in the treatment of intractable epilepsy. More recently, ketotherapeutics have gained increased interest as a potential therapy for the treatment of neurodegenerative disorders and to improve brain aging.
My project aims to determine if there is a link between changes in mitochondrial respiration and levels of tau cleavage. Tau is a microtubule associated protein which aggregates into tangles in the brains of patients with Alzheimer’s disease.
It has been shown that chronic stress alters the functioning of the hypothalamic–pituitary–adrenal (HPA) axis, but the downstream influences on metabolism and the peripheral nervous system have been poorly studied.