Bryce Blankenfeld

2017 - Masters
Primary office:
Mentor: Chris Gamblin, Ph.D.


This tau aggregation into NFTs eventually leads to neuronal death and there are currently no known treatments to slow or prevent the progression of the disease. My doctoral work in Dr. Gamblin’s lab focuses on identifying compounds screened from Aspergillus nidulans secondary metabolites that can inhibit the aggregation of tau and disassemble already formed tau aggregates. Further examination of compounds with inhibition and disassembly activity will be done to determine their interactions by characterizing the binding affinity and binding sites with the tau protein. Another aspect of my research will be to explore the compound structures and to modulate the functional groups or side chains to see if this improves the inhibition or disassembly activities of the compounds.

Memberships

Entered program in the fall of 2014.

Mentor: T. Chris Gamblin, Ph.D., Vanderbilt University

Mentor’s Academic Department: Molecular Biosciences, KU-L

Selected Presentations

Presentations:

2016                     Chemistry-Biology Interface Career Development Conference, University of Michigan        

2016                     10th Annual Drug Discovery for Neurodegeneration Conference, Miami Beach, FL

2015                     NIH Chemical Biology Training Grant Symposium, University of Kansas 

Selected Awards & Honors

Awards:

2016                     Alzheimer’s Drug Discovery Foundation Young Investigator Scholarship Award

2015-2017            NIH Dynamic Aspects of Chemical Biology Fellowship


Contact Information

The University of Kansas
Neuroscience Graduate Program
c/o Dr. Rick Dobrowsky
School of Pharmacy, Ste 2001-D
2010 Becker Drive
Lawrence, KS 66047
Telephone: (785) 864-3531 or (785) 864-3893
E-mail: dobrowsky@ku.edu or psteffan@ku.edu

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