Chronic pain syndromes are a common clinical complaint, yet no good therapeutic is available. To combat this disparity, I will begin research by looking at the effects of CRF1 and CRF2 antagonists on painful bladder syndrome/interstitial cystitis in a neonatal separation mouse model; as well as, doing exploratory research into CRF containing neurons in the periphery using a transgenic mouse model. Depending on the results, I will delve further into the effects of these antagonists on other systems (including off-target negative outcomes) and on other pain syndromes.
June 2014 Joined MD-PhD program, May 2016 Joined lab
Wilkins Heather M, Carl Steven M, Greenlief Alison, Festoff Barry, Swerdlow Russell H . (2014) “Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection”. Frontiers in Aging Neuroscience.